Microbiology

Autism's False Prophets: Bad Science, Risky Medicine, and the Search for a Cure

A London researcher was the first to assert that the combination measles-mumps-rubella vaccine known as MMR caused autism in children. Following this "discovery," a handful of parents declared that a mercury-containing preservative in several vaccines was responsible for the disease. If mercury caused autism, they reasoned, eliminating it from a child's system should treat the disorder. Consequently, a number of untested alternative therapies arose, and, most tragically, in one such treatment, a doctor injected a five-year-old autistic boy with a chemical in an effort to cleanse him of mercury, which stopped his heart instead.

Children with autism have been placed on stringent diets, subjected to high-temperature saunas, bathed in magnetic clay, asked to swallow digestive enzymes and activated charcoal, and injected with various combinations of vitamins, minerals, and acids. Instead of helping, these therapies can hurt those who are most vulnerable, and particularly in the case of autism, they undermine childhood vaccination programs that have saved millions of lives. An overwhelming body of scientific evidence clearly shows that childhood vaccines are safe and does not cause autism. Yet widespread fear of vaccines on the part of parents persists.

In this book, Paul A. Offit, a national expert on vaccines, challenges the modern-day false prophets who have so egregiously misled the public and exposes the opportunism of the lawyers, journalists, celebrities, and politicians who support them. Offit recounts the history of autism research and the exploitation of this tragic condition by advocates and zealots. He considers the manipulation of science in the popular media and the courtroom, and he explores why society is susceptible to the bad science and risky therapies put forward by many antivaccination activists.

The Blind Watchmaker: Why the Evidence of Evolution Reveals a Universe Without Design

Richard Dawkins is not a shy man. Edward Larson's research shows that most scientists today are not formally religious, but Dawkins is an in-your-face atheist in the witty British style:

I want to persuade the reader, not just that the Darwinian world-view happens to be true, but that it is the only known theory that could, in principle, solve the mystery of our existence.

The title of this 1986 work, Dawkins's second book, refers to the Rev. William Paley's 1802 work, Natural Theology, which argued that just as finding a watch would lead you to conclude that a watchmaker must exist, the complexity of living organisms proves that a Creator exists. Not so, says Dawkins: "All appearances to the contrary, the only watchmaker in nature is the blind forces of physics, albeit deployed in a very special way... it is the blind watchmaker."

Dawkins is a hard-core scientist: he doesn't just tell you what is so, he shows you how to find out for yourself. For this book, he wrote Biomorph, one of the first artificial life programs. You can check Dawkins's results on your own Mac or PC.

"The best general account of evolution I have read in recent years."—E. O. Wilson. With a new introduction.

Twenty years after its original publication, The Blind Watchmaker, framed with a new introduction by the author, is as prescient and timely a book as ever. The watchmaker belongs to the eighteenth-century theologian William Paley, who argued that just as a watch is too complicated and functional to have sprung into existence by accident, so too must all living things, with their far greater complexity, be purposefully designed. Charles Darwin's brilliant discovery challenged the creationist arguments; but only Richard Dawkins could have written this elegant riposte. Natural selection—the unconscious, automatic, blind, yet essentially nonrandom process Darwin discovered—is the blind watchmaker in nature.

The Ghost Map: The Story of London's Most Terrifying Epidemic--and How It Changed Science, Cities, and the Modern World

A National Bestseller, a New York Times Notable Book, and an Entertainment Weekly Best Book of the Year

It's the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure-garbage removal, clean water, sewers-necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action-and ultimately solve the most pressing medical riddle of their time.

In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories of the spread of disease, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.

Microcosm: E. coli and the New Science of Life

•Within days of being born, we are infected with billions of E. coli. They will inhabit each and every one of us until we die. E. coli is notorious for making people gravely ill, but engineered strains of the bacteria save millions of lives each year.

•Despite its microscopic size, E.coli contains more than four thousand genes that operate a staggeringly sophisticated network of millions of molecules.

•Scientists are rebuilding E. coli from the ground up, redefining our understanding of life on Earth.

In the tradition of classics like Lewis Thomas's Lives of a Cell, Carl Zimmer has written a fascinating and utterly accessible investigation of what it means to be alive. Zimmer traces E. coli's remarkable history, showing how scientists used it to discover how genes work and then to launch the entire biotechnology industry. While some strains of E. coli grab headlines by causing deadly diseases, scientists are retooling the bacteria to produce everything from human insulin to jet fuel.

Microcosm is the story of the one species on Earth that science knows best of all. It's also a story of life itself--of its rules, its mysteries, and its future.

Microcards: Review Cards for Medical Students

Essential Cell Biology, Second Edition

Essential Cell Biology, Second Edition contains basic, core knowledge about how cells work. It has a proven track record in providing students with a conceptual and accessible grounding in cell biology. The text and figures have been prepared to be easy-to-follow, accurate, clear and engaging for the introductory student. Each section follows logically from the previous one, telling a story, rather than being a collection of facts. Questions integrated throughout each chapter encourage the reader to pause, think about what they have read, and attempt to apply the new knowledge in ways that test their understanding. Based on user feedback, the Second Edition now offers increased coverage of genetics and more experimental background. It is completely up-to-date.

Microbiology: An Introduction, 9th Edition (Book & CD-ROM)

With this Ninth Edition, the “Number One” best-selling non-majors microbiology text extends its trusted and reliable approach with improved disease chapters that feature efficient new “Disease in Focus” boxes, a thoroughly revised immunity chapter (17), new options for the Microbiology Place website/CD-Rom, and a new Media Manager instructor presentation package with 30 multi-step animations. Fundamentals of Microbiology: The Microbial World and You, Chemical Principles, Observing Microorganisms Through a Microscope, Functional Anatomy of Prokaryotic and Eukaryotic Cells, Microbial Metabolism, Microbial Growth, The Control of Microbial Growth, Microbial Genetics, Biotechnology and Recombinant DNA. A Survey of the Microbial World: Classification of Microorganisms, The Prokaryotes: Domains Bacteria and Archaea, The Eukaryotes: Fungi, Algae, Protozoa, and Helminths, Viruses, Viroids, and Prions. Interaction Between Microbe and Host: Principles of Disease and Epidemiology, Microbial Mechanisms of Pathogenicity, Innate Immunity: Nonspecific Defenses of the Host, Adaptive Immunity: Specific Defenses of the Host, Practical Applications of Immunology, Disorders Associated with the Immune System, Antimicrobial Drugs. Microorganisms and Human Disease: Microbial Diseases of the Skin and Eyes, Microbial Diseases of the Nervous System, Microbial Diseases of the Cardiovascular and Lymphatic Systems, Microbial Diseases of the Respiratory System, Microbial Diseases of the Digestive System, Microbial Diseases of the Urinary and Reproductive Systems. Environmental and Applied Microbiology: Environmental Microbiology, Applied and Industrial Microbiology. For all readers interested in microbiology concepts and applications.

The Coming Plague: Newly Emerging Diseases in a World Out of Balance

Where's your next disease coming from? From anywhere in the world--from overflowing sewage in Cairo, from a war zone in Rwanda, from an energy-efficient office building in California, from a pig farm in China or North Carolina. "Preparedness demands understanding," writes Pulitzer-winning journalist Laurie Garrett, and in this precursor to Betrayal of Trust: The Collapse of Global Public Health, she shows a clear understanding of the patterns lying beneath the new diseases in the headlines (AIDS, Lyme) and the old ones resurgent (tuberculosis, cholera). As the human population explodes, ecologies collapse and simplify, and disease organisms move into the gaps. As globalization continues, diseases can move from one country to another as fast as an airplane can fly.

While the human race battles itself ... the advantage moves to the microbes' court. They are our predators and they will be victorious if we, Homo sapiens, do not learn how to live in a rational global village that affords the microbes few opportunities.

Her picture is not entirely bleak. Epidemics grow when a disease outbreak is amplified--by contaminated water supplies, by shared needles, by recirculated air, by prostitution. And controlling the amplifiers of disease is within our power; it's a matter of money, people, and will. --Mary Ellen Curtin

As the global village becomes smaller, as destruction of the rainforests continues, and as bacteria increasingly develop resistance to overused antibiotics, the threat of new diseases, of which AIDS is potentially only the first, becomes ever greater. This book explores the world of new diseases - from AIDS to Toxic Shock Syndrome, Legionnaire's Disease, Ebola (the "Hot Zone" virus) and others - and the over-crowded world we have created that makes these diseases, and their spread, possible.

Clinical Microbiology Made Ridiculously Simple, Edition 3

(Currently in 2004 revised printing) A brief, clear, thorough, and highly enjoyable approach to clinical microbiology, brimming with mnemonics, humor, summary charts and illustrations, from AIDS to "flesh-eating bacteria" to ebola, mad cow disease, hantavirus, anthrax, smallpox, botulism, etc. Excellent Board review.

Microbiology & Immunology: Board Review Series